The Lamen
While spironolactone for acne is an off-label treatment, several women benefit from using the medication to get rid of acne and excessive hair growth.
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Spironolactone is a mineralocorticoid receptor antagonist, currently approved for treating congestive heart failure, cirrhosis, essential hypertension, and edema of pregnancy. However, the drug has seen increasing off-label use for treating acne vulgaris, especially in adult women.
Data-driven: A randomized controlled trial evaluated the effectiveness of oral spironolactone for women with acne vulgaris over 24 weeks.
What’s notable: Experts suggest that more clinical testing is required to support spironolactone use as a viable alternative to antibiotics for treating acne, especially as the downsides of antimicrobial resistance become apparent.
Spironolactone acts as an antagonist to aldosterone, a hormone that controls water and salt regulation throughout the body. By competing with aldosterone for receptor sites, spironolactone makes it so your body doesn’t retain fluid.
Available both as a topical agent and a pill, spironolactone has been recommended by dermatologists for years when treating hormonal acne in women.
The state of things: Despite being in use for nearly 50 years, spironolactone has not been approved for the management of acne. However, off-label use of the drug for treating acne, specifically in females, has been steadily gaining popularity.
Widespread adoption of spironolactone for treating women with acne would help reduce the long-term prescription of oral antibiotics.
Spironolactone works best over a longer treatment duration (3 months) and may need to be combined with topical agents for better results.
Spironolactone is a prescription medication that is recommended for use by women only, as the drug interferes with androgens. Being a diuretic, the drug will cause excessive urination.
Commonly reported side effects of taking spironolactone include:
Some health conditions may also worsen when taking spironolactone, including:
People looking to get pregnant or already pregnant should avoid using spironolactone, as the drug may cause birth defects and feminization of the male fetus.